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To verify the involvement of BT in the metabolism of bile acids, the hdhA deletion mutant (BT hdhA) and replenishment strains were constructed, and the bacteria were cultured with CDCA under an anaerobic condition

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In microglia, GLP-1R activation via PI3K/Akt signaling also reduces neuroinflammation by modulating NF-B activity, decreases the production of pro-inflammatory cytokines, increases anti-inflammatory markers such as IL-10, IL-4, Arginase, and CD206, and the transformation of microglia into an anti-inflammatory state